Other pathological modifications to the cGAS-STING pathway, such as mutations of the exonuclease Trex1, have been linked to several other autoimmune conditions, including Aicardi-Goutières syndrome (AGS), SLE, familial chilblain lupus and retinal vasculopathy with cerebral leukodystrophy (RVCL) [197–199]. This evidence concerns the gene CGAS and systemic lupus erythematosus.