CGAS and cancer: While the implications of cGAS/STING deficiency in cancer cells on immune clearance were not explored in these studies, it is possible that under such circumstances, cGAS-STING signaling is taken over by stromal or infiltrating immune cell cGAS/STING via the other previously described mechanisms (direct uptake of tumor dsDNA, cGAMP, or phagocytosis of tumor cells).