Since MK-2206 is one of the most potent and best-studied Akt agonists, we designed a series of studies around this agent to determine whether a phenotypically diverse panel of breast cancer lines would be susceptible to combined action of Th1 cytokines and MK-2206, whether this combination would enhance cell death through an apoptotic mechanism, and determine the effect of this treatment on the expression of important oncodrivers by breast cancer cells. Here, AKT1 is linked to breast carcinoma.