DNMT1 and metabolic syndrome: Sham operation failed to produce the significant modulation on DNMT-1 expression in the cerebral cortex of MetS rats induced by HCHF diet whereas MCAO significantly enhanced DNMT-1 expression in the cerebral cortex of MetS rats (p values < 0.001; compared to normal diet-fed rats which received vehicle; p values < 0.01; compared to compared to the HCHF+sham operation+vehicle group).