It was found that MetS rats induced by HCHF diet which subjected to sham operation failed to produce the significant modulation on PPARγ expression, whereas MCAO significantly decreased PPARγ expression in the cerebral cortex of MetS rats (p values < 0.001; compared to normal diet-fed rats which received vehicle; p values < 0.001; compared to compared to the HCHF+sham operation+vehicle group). This evidence concerns the gene PPARG and metabolic syndrome.