NFE2L2 and esophageal squamous cell carcinoma: Alpinumisoflavone (AIF) could significantly increase the radiosensitivity of esophageal squamous cell carcinoma (ESCC) indicated by enhanced apoptosis, DNA damage, and cell cycle arrest which are mechanically achieved by ROS generation and Nrf2 antioxidant system inhibition both in vitro and in vivo [218].