A recent clinical study reported that 3 d of oral Dasatinib and Quercetin alleviated adipose tissue senescent cell burden and decreased skin epidermal p16INK4A+ and p21CIP1+ cells and circulating SASP factors in patients with DN, indicating that senolytics relieved senescent cell burden [216]. This evidence concerns the gene CDKN1A and liver dysplastic nodule.