IGHE and Autoimmunity: Intriguingly, we found 2 major differences between r-CSU and Or-CSU in our study: High total IgE levels (associated with type I autoimmunity) were related to Or-CSU phenotype (18% vs 41%, respectively) while concomitant autoimmunity (which may support type II autoimmunity) was related to r-CSU phenotype (55% vs. 20%, respectively).