This prevalence (42.86%) recorded in this study is lower than that reported by Njunda et al. [15] and Nweze et al. [14], where prevalence of 54.1% and 60% were recorded respectively, these difference could probably be due to the fact that not all participants in these studies were on HAART and the advent of HAART has allowed for the suppression of viral replication to very low levels and a partial recovery of CD4 cells in patients with HIV, which has consequently reduced opportunistic infections.[11, 21, 22]. This evidence concerns the gene CD4 and Opportunistic infection.