Nevertheless, Li et al. [60], Huang et al. [61], and Lu et al. [62] indicated that although GPR is a novel diagnostic model for liver fibrosis or cirrhosis, it does not display advantages compared to APRI and FIB-4 for identifying significant fibrosis, severe fibrosis, and cirrhosis in Chinese CHB patients. This evidence concerns the gene ALDH18A1 and Hepatic fibrosis.