BACE1 and Alzheimer disease: Liang Feng et al. compared the plasma levels of 4 lncRNAs between AD patients and non-AD patients and found that the β-amyloid precursor protein lyase 1 (BACE1) level in the plasma of AD patients was increased and was highly specific to AD (88%), suggesting that BACE1 may be a potential candidate biomarker to predict AD [3].