TGFB1 and pancreatic adenocarcinoma: Our research group previously identified that paeonol could inhibit epithelial-mesenchymal transition of pancreatic adenocarcinoma in vitro via suppressing the transforming growth factor beta 1(TGF-β1)/SMAD signaling pathway provided some evidence for future investigation into the antimetastasis effect of Cynanchum paniculatum and its derivatives [112].