PPARG and early-onset autosomal dominant Alzheimer disease: The relationship between EA and PPARγ has been explored in patients with Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2) [8, 9] and it was reported that PPARγ played a crucial role in anti-inflammatory activities [28] and activation of PPARγ, which is known to be essential for the inflammation-suppressive effects, like inflammatory cytokine production and mitochondrial activities [29, 30].