For in vitro experiments, the migration and growth of human CRC cells were inhibited by JPFR extract in a dose-dependent way, and the expression of MALAT1, PTBP-2, β-catenin, MMP7, c-Myc, and Cyclin D1 in CRC cells was downregulated by JPFR extract in a dose-dependent way. This evidence concerns the gene PTBP2 and colorectal carcinoma.