For example, mRNA levels of miRNA maturation machinery—Drosha, Dgcr8, Dicer, and Argonaute-2—are significantly increased in vitro in the human umbilical vein endothelial cells (HUVECs) by hyperglycemia, indicating that Dicer or miRNAs are sensitive to nutrient alterations [6]. This evidence concerns the gene DICER1 and Hyperglycemia.