Promyelocytic leukemia nuclear bodies (PML-NBs) are nuclear membraneless organelles which contain several cellular proteins, among them mainly PML protein, involved in intrinsic antiviral responses against a number of viruses (Borden, 2002; Geoffroy and Chelbi-Alix, 2011; Scherer and Stamminger, 2016; Guion and Sapp, 2020). This evidence concerns the gene PML and acute promyelocytic leukemia.