TNNI3 and heart disorder: However, we did not find any associations between the I/D polymorphism and the cTnI and NT-proBNP values in an univariate analysis, which is in accordance with a previous study on 241 cardiac patients (Alazhary et al., 2015), and a meta-analysis (Bai et al., 2012) on the association of ACE gene with heart disease.