ADN-KO mice displayed not only cognitive impairments, but also LTP deficits of the hippocampal Schaefer collateral pathway and altered levels of key presynaptic and postsynaptic proteins involved in glutamatergic neurotransmission, together suggesting that adiponectin is a crucial regulator of cognition and synaptic function (Bloemer et al., 2019). The gene discussed is ADIPOQ; the disease is Cognitive impairment.