With the infection of CSFV on recombinant PK15 or ST cells, the expression of rE2 protein driven by swine endogenous Txnip promoter could also been accelerated by introduction of inflammasome caused by virus infection and replication in host cells, since E2 and other non‐structure viral proteins had been tested with the trigger of NLRP3 inflammasome in infected host cells [31, 32]. Here, GPR161 is linked to infection.