As a fact, androgens strongly upregulate TMPRSS2 expression in prostate tumor cells and they can also control, and upregulate, the oncogenic transcription factor ERG, normally androgen-insensible, when the TMPRSS2:ERG fusion gene is produced because of somatic gene rearrangements in prostate cancers [57]. This evidence concerns the gene TMPRSS2 and prostate carcinoma.