As a consequence, patients not only develop a severe pneumonia but also exhibit a sort of macrophage activation syndrome/cytokine release syndrome (CRS) with deranged liver function tests, diffuse endothelial damage and coagulopathy, mirrored by circulating high D-dimer, hyperferritinaemia and high C-reactive protein evolving towards a multi-organ failure [79]. The gene discussed is CRP; the disease is congenital rubella syndrome.