HES1 and metastatic malignant neoplasm in the lymph nodes: Another report claimed that highly expressed DLX6-AS1 was associated with lymph node metastasis and poor prognosis of OC patients, and downregulation of DLX6-AS1 blocked the expression of Notch1, p21, and Hes1, leading to the suppression of proliferation, migration and invasion in OC cells [30].