ERBB2 and lip and oral cavity carcinoma: Previous research by our group showed that E6/E7 of HPV type 16 along with ErbB-2, which is upregulated in 30% of oral carcinomas  [77], induce cellular transformation of oral epithelial cells [46] via β-catenin tyrosine phosphorylation by pp60 (c-Src) kinase activation [46, 78].