IL-1β and IFN-γ were 15~20 pg/ml and 4~6 pg/ml at 24 h and 48 h in the early stage of CLP but significantly increased to 20~40 pg/ml and 10-20 pg/ml in the late sepsis (Figures 4(d) and 4(e)). Here, IL1B is linked to Sepsis.