Numerous other molecular mechanisms were suggested for the pro-apoptotic effect of SF, such as the cleavage of caspase-8 in pancreatic cancer,35 the fragmentation of the DNA-repairing protein poly (ADP-ribose) polymerase (PARP) and decreased expression of BCL2 in mammary, prostate and colon cancers.36–38. Here, CASP8 is linked to colonic neoplasm.