These findings were addressed in our previous work using the same cohort where we showed lower rates of high-risk DCIS over time, which was reflected by higher rate of BCS as a primary surgical management, lower rate of second operation27 and decreased the proportion of HER2-positive DCIS over time.29 Moreover, the protocol for management of DCIS in routine practice changed over time. Here, ERBB2 is linked to ductal breast carcinoma in situ.