In agreement with our in vivo experiments on Eip75B-A /- C in EB differentiation (Figures 3–7), in vitro studies identified PPARγ promoting differentiation in various colon cancer cell lines (Cesario et al., 2006; Shimizu and Moriwaki, 2008; Yamazaki et al., 2007; Yoshizumi et al., 2004). This evidence concerns the gene PPARG and malignant colon neoplasm.