In a CRC mouse model, biallelic loss of PPARγ leads to a 4-fold increase tumor incidence and reduced survival in female mice over males (ApcMin/+/PPARγ-/-) (McAlpine et al., 2006), whereas males develop around three times more colon tumors with wild type PPARγ (Cooper et al., 2005). The gene discussed is PPARG; the disease is neoplasm.