Among these, examples of pQTLs with corresponding effects at the RNA level include the variant rs7872034, a pQTL for SMC2 with co-localisation evidence for serous invasive ovarian cancer (Phelan et al., 2017), and the variant rs11752813, a pQTL for PEX6 and in LD with Alzheimer's disease in APOE e4+ carriers risk variant rs1129187 (Jun et al., 2016; Figure 2—figure supplement 4; Figure 2b). Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.