Kuchenbaecker et al. estimated the cumulative breast cancer risk to age 80 years to be 72% (95% confidence interval (CI) = 65–79%) and 69% (95% CI = 61–77%) for BRCA1 and BRCA2 pathogenic variant carriers, respectively (Kuchenbaecker et al., 2017). The gene discussed is BRCA2; the disease is breast carcinoma.