The cytokine profiles involved in CRS following CAR-T cells therapy encompass the effector cytokines such as IL-1RA, IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-15, IL-18, TGF-β, IFN-α, IFN-γ, TNF-α, VEGF, MIP-1α, MIP-1β, soluble IL-2Rα, soluble IL-6R, granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemotactic protein (MCP)-1, ferritin, C-reactive protein (CRP) and MIP-1α, etc [4,13,14]. This evidence concerns the gene IL18 and congenital rubella syndrome.