Altogether our study indicates that strategies aimed at targeting TREM2 on microglia in the CNS are feasible and might be a promising intervention in MS to promote microglia functions in clearing myelin debris, favoring the recruitment of OPCs, and their subsequent differentiation into mature myelin-generating oligodendrocytes, eventually leading to remyelination and axonal protection. The gene discussed is TREM2; the disease is myeloid sarcoma.