IFNB1 and infection: The promoter activity of IFNB1 or ISRE and the production of IFN-β were significantly higher when HDAC3 was overexpressed as compared to samples transfected with the empty vector rather than HDAC3 deacetylase inactive mutant (H134Q), and the agonists occurred in a dose-dependent manner after infection with SeV (Fig. 1D and 1E).