LDLR and atherosclerosis: Also implicated in cholesterol homeostasis is LeXis (Liver-expressed Liver X Receptor (LXR)–induced sequence) [35], a lncRNA that binds the ribonucleoprotein RALY in hepatocytes, and inhibits its occupancy at cholesterol biosynthetic gene promoters, such as Srebf2. Using a liver-specific adeno-associated virus (AAV8)–based gene approach to increase LeXis expression in western diet (WD)–fed Ldlr−/− mice was associated with a decrease in hepatic and circulating lipid levels and reduced atherosclerosis [36].