Knowing that we have not analyzed the CSF of all patients in our cohort, the hypothesis of an inflammatory component in the emergence of the COVID-19 delirium is supported by (i) the absence of RNA viral load in CSF at the time of the diagnosis of COVID-19 except in one patient; (ii) CSF analysis revealing mirror pattern of oligoclonal bands, elevated protein and IgG level, and elevated proinflammatory cytokine IL-6; and (iii) brain imaging showing subarachnoid contrast enhancement suggestive of abnormal permeability of the blood meningeal barrier associated with the encephalopathy. This evidence concerns the gene IL6 and COVID-19.