For example, lncRNA-PVT1 promotes PC cell proliferation and migration by sponging miR-448 [24]; cucurbitacin B inhibits PC cell proliferation both in vitro and in vivo through lncRNA-AFAP1-AS1 binding with miR-146b-5p [25]; and PXN-AS1 acts as a ceRNA of miR-3064, which upregulates PIP4K2B expression and suppresses the progression of pancreatic cancer [26]. The gene discussed is PXN; the disease is pachyonychia congenita.