For instance, LINC00346 accelerated PC progression and gemcitabine resistance partially through the miR-188-3p/BRD4 axis [20]; lncRNA GLS-AS mediated the feedback loop of Myc and GLS and provided a potential therapeutic strategy for metabolic reprogramming in PC [21]; AFAP1-AS1 was shown to exert inhibitory effects on the stemness of PC cells and ultimately PC tumorigenicity in vivo via the miR-384/ACVR1 axis [22]. This evidence concerns the gene BRD4 and pachyonychia congenita.