Additionally, we also defined the molecular mechanism underlying how IL13Rα1 combats the apoptotic resistance of RA FLSs against ER stress that IL13Rα1 could activate Trail-DR5 signaling pathway through upregulating the expression of the trail via activating STAT6 and simultaneously interact and stabilize the receptor of the trail, DR5. This evidence concerns the gene STAT6 and rheumatoid arthritis.