RUNX3 and breast carcinoma: Subsequently, we analysed the correlation between RCAN 1.4 and these 37 transcription factors at the transcriptional level in breast cancer patients using the TCGA database, and found ATF3 (Activating Transcription Factor 3) and RUNX3 (RUNX Family Transcription Factor 3) were the top two genes that were most closely and positively correlated with RCAN1.4 in breast cancer tissues (Fig. 5b).