In individuals with Down syndrome and a mouse model of Down syndrome, the modest elevation in expression afforded by a single extra transgenic copy of RCAN1.4 is sufficient to confer significant suppression of tumour growth in mice and that resistance is a consequence of a deficit in tumour angiogenesis arising from suppression of the VEGF- CaN/NFAT pathway [31]. The gene discussed is VEGFA; the disease is neoplasm.