Furthermore, by comparing lung tumor rates between FVB/N-SPC-TP53-273H and A/J-SPC-TP53-273H transgenic mice, we found that the A/J-SPC-TP53-273H transgenic mice have a higher lung cancer rate (Fig. 3a), which may be due to an increased sensitivity in this strain. This evidence concerns the gene TP53 and lung cancer.