Several of the pathways outlined in Additional file 4: Table S4 play important roles in immunity (e.g. chemokine signaling, B cell receptor signaling and T cell receptor signaling), cancer (e.g. endometrial cancer, proteoglycans in cancer, thyroid cancer), as well as in oncogenic signaling (e.g. Ras and ErbB signaling) (see Additional file 4: Table S4), but most of them are not significant after correction for multiple testing. The gene discussed is EGFR; the disease is endometrial cancer.