However, the precise nature of LRP1 involvement in AD pathogenesis is still widely debated (Kanekiyo & Bu, 2014; Shinohara, Tachibana, Kanekiyo, & Bu, 2017); nevertheless, the ability to interact with ApoE‐Aβ complex, and this novel interaction with tau, makes LRP1 an emerging link between major players of AD pathology. This evidence concerns the gene LRP1 and Alzheimer disease.