Studies based on tau PET of AD patients coupled with mathematical predictions modelling tau spread in the human brain, have also supported the importance of neuronal connectivity in this process (Alzheimer’s Disease Neuroimaging Initiative et al., 2020; Franzmeier, Rubinski, Neitzel, Kim, et al., 2019; Hoenig et al., 2018; Jacobs et al., 2018). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.