APOE and Alzheimer disease: However, the precise nature of LRP1 involvement in AD pathogenesis is still widely debated (Kanekiyo & Bu, 2014; Shinohara, Tachibana, Kanekiyo, & Bu, 2017); nevertheless, the ability to interact with ApoE‐Aβ complex, and this novel interaction with tau, makes LRP1 an emerging link between major players of AD pathology.