Many LRP1 ligands have been linked to AD pathology, including ApoE (Rebeck, Reiter, Strickland, & Hyman, 1993), cell‐surface amyloid precursor protein (Knauer, Orlando, & Glabe, 1996) and secreted amyloid precursor protein (Kounnas et al., 1995). Here, LRP1 is linked to Alzheimer disease.