Correspondingly, a rich body of preclinical studies showed that Nlrp3 deficiency in mice protects against inflammatory pathology in models of gout, pseudogout, atherosclerosis, inflammatory arthritis, non‐alcoholic steatohepatitis (NASH), Alzheimer's disease (AD), and the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis.46, 47, 48, 49, 50, 51, 52, 53, 54. This evidence concerns the gene NLRP3 and atherosclerosis.