NLRP1 and arthritic joint disease: However, dominantly inherited gain‐of‐function mutations in human NLRP1 predispose patients to the development of Mendelian diseases characterized by skin inflammation and dyskeratosis named multiple self‐healing palmoplantar carcinoma (MSPC), NLRP1‐associated autoinflammation with arthritis and dyskeratosis (NAIAD), and autoinflammation with arthritis and dyskeratosis (AIADK).29, 30