However, the Studies of Left Ventricular Dysfunction (SOLVD), which enrolled a small percentage of women, showed a reduction in combined mortality or HF hospitalization from 39.5% in the placebo arm to 29.7% in the ACE inhibitor enalapril arm in men compared with non-significant reduction from 38.7 to 37% in women [76]. Here, ACE is linked to hydrops fetalis.