Tns (I-T) serial changes are associated with variations of EF after chemotherapy administration: Sawaya et al. found that elevated high-sensitive troponin I (TnI) levels, together with echocardiographic markers of myocardial deformation, predicted the occurrence of cardiotoxicity among breast cancer patients receiving anthracycline and trastuzumab [47]. This evidence concerns the gene TNS1 and breast carcinoma.