NRAS and neoplasm: The best compound 3144 was tested against a number of different cell lines with WT and mutant NRAS (G13D, G13V), and selective inhibition was observed against mutant NRAS cells; moreover, it was able to decrease tumour growth in MDA-MB-231 (KRAS-G13D) and PDTALL22 (NRAS-G13V) xenograft mouse models.