CD274 and non-small cell lung carcinoma: Although the expression of both CMTM6 and PD-L1 is induced by related immunoregulatory factors, a previous report indicated that in advanced-stage non-small-cell lung cancer, the proportion of CMTM6-high/PD-L1+ cells is low, and some cases with PD-L1− contain high expression of CMTM6 [18].