The SSc disease module from the KEGG pathways was most strongly enriched with the MAPK-signaling pathway (P value = 2.85 × 10−80), PI3K-Akt-signaling pathway (P value = 8.09 × 10−69) and tumor necrosis factr (TNF)-signaling pathway (P value = 1.55 × 10−64), followed by the chemokine-signaling pathway (P value = 7.70 × 10−42), Fcε RI-signaling pathway (P value = 3.32 × 10−45) and the JAK-STAT signaling pathway (P value = 2.09 × 10−40). This evidence concerns the gene TNF and systemic sclerosis.