For the younger MCL patients receiving cytarabine-containing chemotherapy and autologous stem cell transplantation, Ferrero et al.9 developed the MIPI-genetic index (MIPI-g), which is a prognostic model integrating MIPI-c prognostic index with genetic data (TP53, and KMT2D mutations). The gene discussed is TP53; the disease is mantle cell lymphoma.