When used in combination with TMZ, NF-κB inhibitor parthenolide has been shown to activate mitochondrial apoptosis signaling in U87MG and U373 GBM cells, which lead to cell death18 and had a combined effect on cell cytotoxicity in LN18 and T98G glioma cells19. The gene discussed is NFKB1; the disease is glioblastoma.