MAPT and Alzheimer disease: The misfolding and aggregation of tau, a microtubule-associated IDP, into highly ordered β-sheet-rich fibrils, paired helical filaments (PHFs), that subsequently deposit into neurofibrillary tangles (NFTs) inside neurons are implicated in a range of neurodegenerative disorders, collectively termed tauopathies that include Alzheimer’s disease (AD), Pick’s disease, and frontotemporal dementia with parkinsonism-1711,14.