The bone marrows of vehicle and Day 1,4 but not Day 1,2 treated mice, were replaced by AML cells observed by microscopy (Supplementary Fig. S4B) and by flow cytometry: human CD45+ (hCD45+) AML cells were ~92% with PBS, ~63% with Day 1,4 and ~26% with Day 1,2 treatment (Supplementary Fig. S4C). The gene discussed is PTPRC; the disease is acute myeloid leukemia.