Bone marrow cells harvested at day 63, when leukemia-innoculated mice were doing well on-therapy, demonstrated that the treatments depleted DNMT1, with the greatest depletions with THU + decitabine alternating with THU + 5-azacytidine week-to-week (~65% DNMT1-depletion) versus THU + decitabine (~50%), decitabine alone (~35%) or vehicle (~15%) (Fig. 6e). Here, DNMT1 is linked to leukemia.