We observed that Methionine synthase rs1805087 A/G variant is associated with an elevated risk of PCa (G-allele vs. A-allele: OR = 1.06, 95% CI = 1.01–1.11, P = 0.013; heterozygous model: OR = 1.08, 95% CI = 1.02–1.14, P = 0.009; dominant model: OR = 1.08, 95% CI = 1.02–1.14, P = 0.007). This evidence concerns the gene MTR and posterior cortical atrophy.