Additionally, an increase in CXCR6 expression in NKT cells and subsequent binding to CXCL16, which is expressed in endothelial cells and macrophages, in NASH can lead to the accumulation of NKT cells that produce proinflammatory cytokines such as IL-4, IFN-γ, and TNF-α, thus inducing inflammation via macrophage activation65 (Fig. 1). The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.