HSPB1 and Alzheimer disease: For each clinical and neuropathological trait, the protein with the highest log(FC) was Aβ (mass spectrometry measurement, referred throughout the paper as Aβ), followed by other known AD proteins such as MAPT, GFAP, HSPB1, RPH3A, SYT1, and PADI2 (Supplementary Table 3).