Increased levels of Tau phosphorylation, observed in the clusters formed by dystrophic neurites around amyloid plaques in brains of human patients and mouse AD models50,51 including 5xFAD, were reduced by germline VGF overexpression in 5xFAD,VGFΔ/Δ mice (Fig. 5c), while reduced levels of postsynaptic density (PSD)-associated protein PSD-95 in 5xFAD hippocampus (CA1) were significantly increased (Supplementary Fig. 5). This evidence concerns the gene DLG4 and Alzheimer disease.