In addition, adult hippocampal neurogenesis is impaired in human subjects with AD48, and rapid and aggressive amyloid pathology in 5xFAD was associated with reduced neuron numbers and neurogenesis in the subgranular zone of the hippocampus49, which was fully rescued by VGF germline overexpression in male and female 5xFAD (Fig. 5b). This evidence concerns the gene VGF and amyloidosis.