We chose dHc because: (i) VGF peptide administration to dHC of wild-type (WT) mice has pro-cognitive efficacy14; (ii) local VGF ablation in mouse dHC results in memory deficits14; (iii) dHc has proximity to the ectorhinal area, which sustains the most damage in AD and where VGF is significantly downregulated for multiple AD features. Here, VGF is linked to Alzheimer disease.