Notably, compared to epithelial liver cancer lines, HNF4α-negative mesenchymal liver cancer lines also showed increased resistance to cell death induced by sorafenib when cultured in complete medium, and methionine/cystine restriction failed to enhance the effect of sorafenib in these cells (Fig. 3e, SNU449 and SNU475). The gene discussed is HNF4A; the disease is liver cancer.