HNF4A and liver cancer: Remarkably, metabolites involved in SAA metabolism were the most significantly enriched metabolites among the 34 metabolites that were significantly changed in the same direction in both HNF4α-depleted HepG2 cells and SNU449 cells (Fig. 5g and Supplementary Table 3), suggesting that impaired SAA metabolism is one of the major shared metabolic characteristics of HNF4-depleted epithelial cells and HNF4-negative mesenchymal liver cancer cells.