Consistent with their clustering patterns, the expression of five key SAA metabolic genes, MAT1A, BHMT, CBS, CTH, and CDO1, was positively correlated with that of HNF4α in both non-viral and viral HCC patients (Fig. 1c, Supplementary Fig. 2a, b). The gene discussed is HNF4A; the disease is hepatocellular carcinoma.