To further understand how HNF4α regulates SAA metabolism and the resulting cellular sensitivity to methionine/cystine restriction and sorafenib, we tested whether SAA metabolic enzymes are direct transcription targets of HNF4α since the expression of HNF4α is strongly correlated with those of SAA metabolic genes in liver cancer (Fig. 1 and Supplementary Fig. 1). This evidence concerns the gene HNF4A and liver cancer.