HNF4A and liver cancer: Notably, knocking down HNF4α in three epithelial liver cancer cell lines increased resistance to cell death induced by methionine/cystine restriction (reduced apoptosis in Fig. 6d, and increased surviving cell number in 6e and Supplementary Fig. 7b, siHNF4α vs. siNeg) or sorafenib treatment (Fig. 6f, g, and Supplementary Fig. 7b, siHNF4α Sorafenib vs. siNeg Sorafenib).