Feeding mice with the MCR diet significantly inhibited the growth of xenografted control HepG2 tumors with enhanced tumor damage and death in vivo (Fig. 6h and Supplementary Fig. 9b, siNeg MCR vs. siNeg CTR), whereas knocking down HNF4α significantly blunted the inhibitory impact of the MCR diet on the growth and proliferation of HepG2 tumors (Fig. 6h, i and Supplementary Fig. 6d, siHNF4α MCR vs. siNeg MCR). The gene discussed is NR3C2; the disease is neoplasm.